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23 Downtown Durham, Durham, NC Commercial Real Estate Listings

  • Durham Bottling Company - Durham
    Coworking

    Durham Bottling Company

    Durham Bottling Company
    506 Ramseur Street, Durham, NC
    Services
    • Virtual Office
    • Open Workspace
    • Event Space
    • Meeting Room
    • Private Office
    Amenities
    View Details
  • 701 William Vickers Avenue - Durham

    701 William Vickers Avenue

    701 William Vickers Avenue, Downtown Durham, Durham, NC
    For Lease
    • $23.00/SF/YR
    Property
    • Office
    • 4,806 SF
    Availability
    • 1 Space
    • 4,806 SF
    Year Built
    • 1956
    View Details
  • American Tobacco Campus - Durham

    American Tobacco Campus

    324 Blackwell Street, Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Office
    • 16,553 SF
    Availability
    • 2 Spaces
    • 11,996 SF
    View Details
  • 101 W Main Street - Durham

    101 W Main Street

    101 W Main Street, Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Office
    • 5,153 SF
    Availability
    • 1 Space
    • 5,153 SF
    View Details
  • The Tower at Mutual Plaza - Durham

    The Tower at Mutual Plaza

    411 West Chapel Hill Street, Downtown Durham, Durham, NC
    For Lease
    • $33.50/SF/YR
    Property
    • Office
    • 183,835 SF
    Availability
    • 5 Spaces
    • 65,496 SF
    Year Built
    • 1965
    View Details
  • 105 W. Main Street - Durham

    105 W. Main Street

    105 W. Main Street, Downtown Durham, Durham, NC
    For Sale
    • $2,200,000
    Property
    • Retail
    • 7,820 SF
    Year Built
    • 1908
    View Details
  • 505 South Duke Street - Durham

    505 South Duke Street

    505 South Duke Street, Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Office
    • 45,804 SF
    Availability
    • 1 Space
    • 4,897 SF
    Year Built
    • 1972
    View Details
  • 300 E. Main St. - Durham

    300 E. Main St.

    300 E. Main St., Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Office
    • 30,517 SF
    Availability
    • 3 Spaces
    • 11,391 SF
    Year Built
    • 1925
    View Details
  • American Tobacco Campus - Durham

    American Tobacco Campus

    406 & 410 Blackwell Street, Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Office
    • 46,998 SF
    Availability
    • 1 Space
    • 46,998 SF
    View Details
  • Diamond View II - Durham

    Diamond View II

    280 S Mangum Street, Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Office
    • 156,770 SF
    Availability
    • 2 Spaces
    • 41,157 SF
    Year Built
    • 2008
    View Details
  • Venable Center - Durham

    Venable Center

    303 South Roxboro Street, Downtown Durham, Durham, NC
    For Lease
    • $36.50/SF/YR
    Property
    • Office
    • 85,886 SF
    Availability
    • 1 Space
    • 11,446 SF
    Year Built
    • 2006
    View Details
  • 201 West Main Street - Durham
    Coworking

    201 West Main Street

    American Underground
    201 West Main Street #100, Durham, NC
    Services
    • Open Workspace
    • Private Office
    Amenities
    View Details
  • 102 East Main Street - Durham
    Coworking

    102 East Main Street

    The Chill Place
    102 East Main Street #100, Durham, NC
    Services
    • Open Workspace
    • Meeting Room
    • Private Office
    Amenities
    View Details
  • The Roxboro at Venable Center - Durham

    The Roxboro at Venable Center

    464 East Pettigrew Street, Downtown Durham, Durham, NC
    For Lease
    • $39.50/SF/YR
    Property
    • Office
    • 210,410 SF
    Availability
    • 9 Spaces
    • 203,249 SF
    Year Built
    • 2022
    View Details
  • 100 E Parrish St - Durham

    100 E Parrish St

    100 E Parrish St, Downtown Durham, Durham, NC
    For Sale
    • $1,000,000
    Property
    • Office
    • 3,860 SF
    Year Built
    • 1984
    View Details
  • Rogers Alley - Durham

    Rogers Alley

    107 East Parrish Street, Downtown Durham, Durham, NC
    For Lease
    • $29.50/SF/YR
    Property
    • Office
    • 6,485 SF
    Availability
    • 2 Spaces
    • 6,485 SF
    View Details
  • 555 Mangum - Durham

    555 Mangum

    555 South Mangum Street, Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Office
    • 242,063 SF
    Availability
    • 7 Spaces
    • 107,958 SF
    Year Built
    • 2020
    View Details
  • Ramseur Assemblage - Durham

    Ramseur Assemblage

    506/608 E Ramseur and 618 E Ramseur Street, Downtown Durham, Durham, NC
    For Sale
    • Subject to offer
    Property
    • Office
    • 27,200 SF
    View Details
  • Durham Kress - Durham

    Durham Kress

    101-103 W Main Street, Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Office
    • 24,500 SF
    Availability
    • 1 Space
    • 7,306 SF
    Year Built
    • 1907
    View Details
  • 204 South Gregson Street - Durham

    204 South Gregson Street

    204 South Gregson Street, Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Office
    • 218,000 SF
    Availability
    • 1 Space
    • 218,000 SF
    Year Built
    • 2023
    View Details
  • 100 E Parrish St Suite 100 - Durham

    100 E Parrish St Suite 100

    100 E Parrish St, Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Office
    • 2,000 SF
    Availability Contact for availability
    Year Built
    • 1984
    View Details
  • Brightleaf Square - Durham

    Brightleaf Square

    905 West Main Street, Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Retail
    • 139,785 SF
    Availability
    • 10 Spaces
    • 25,595 SF
    Year Built
    • 1904
    View Details
  • 112 S Duke St - Durham

    112 S Duke St

    112 S Duke St, Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Office
    • 16,203 SF
    Availability
    • 4 Spaces
    • 15,085 SF
    Year Built
    • 1910
    View Details

Commercial Spaces for Lease and Sale

If you are looking for commercial real estate for lease and sale in Downtown Durham, Durham, NC that is perfect for your business needs, look no further than the 27 listings that are currently available locally. Available spaces amount to a total of 787,018 square feet and span several popular locations and high-value submarkets. Commercial spaces currently listed in Downtown Durham, Durham, NC cover a wide range of needs in terms of size and range up to 218,000 square feet. Easily focus your search using the intuitive tools and filters available on this page and locate the perfect commercial real estate listing for you!

Market News

The 42Floors blog keeps you in the loop on commercial real estate news and market insights, as well as coworking and shared space trends.

Double Lease Deal at 261 Fifth Ave. After Marketing & Beauty Brand Signing

Double Lease Deal at 261 Fifth Ave. After Marketing & Beauty Brand Signing

The new lease momentum continues at 261 Fifth Ave., the landmark New York City building: Bold PR — a specialist in PR and media in the beauty industry — has leased 6,195 square feet of built-to-suit space at the Midtown office space. Additionally, Biologique Research, an upscale French skin care...

January 31, 2023

Dr. Timothy Riddiough Discusses the CRE Market

Dr. Timothy Riddiough Discusses the CRE Market

For our latest interview, we had the pleasure of speaking with Timothy Riddiough, who holds the James A. Graaskamp Chair and is a professor in the Department of Real Estate and Urban Land Economics at the Wisconsin School of Business. Dr. Riddiough served as department chair of Real Estate and U...

January 16, 2023

Bridge Group & Steerpoint Capital Buy Northridge Mall

Bridge Group & Steerpoint Capital Buy Northridge Mall

With its existing assets and notable potential, the new owners believe Northridge Mall can become a dominant retail destination in the region and the broader market.

January 13, 2023