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23 Downtown Durham, Durham, NC Commercial Real Estate Listings

  • Durham Bottling Company - Durham
    Coworking

    Durham Bottling Company

    Durham Bottling Company
    506 Ramseur Street, Durham, NC
    Services
    • Virtual Office
    • Open Workspace
    • Event Space
    • Meeting Room
    • Private Office
    Amenities
    View Details
  • 701 William Vickers Avenue - Durham
    701 William Vickers Avenue, Downtown Durham, Durham, NC
    For Lease
    • $23.00/SF/YR
    Property
    • Office
    • 4,806 SF
    Availability
    • 1 Space
    • 4,806 SF
    Year Built
    • 1956
    View Details
  • American Tobacco Campus - Durham
    324 Blackwell Street, Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Office
    • 16,553 SF
    Availability
    • 2 Spaces
    • 11,996 SF
    View Details
  • 101 W Main Street - Durham
    101 W Main Street, Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Office
    • 5,153 SF
    Availability
    • 1 Space
    • 5,153 SF
    View Details
  • The Tower at Mutual Plaza - Durham
    411 West Chapel Hill Street, Downtown Durham, Durham, NC
    For Lease
    • $33.50/SF/YR
    Property
    • Office
    • 183,835 SF
    Availability
    • 5 Spaces
    • 65,496 SF
    Year Built
    • 1965
    View Details
  • 105 W. Main Street - Durham
    105 W. Main Street, Downtown Durham, Durham, NC
    For Sale
    • $2,200,000
    Property
    • Retail
    • 7,820 SF
    Year Built
    • 1908
    View Details
  • 505 South Duke Street - Durham
    505 South Duke Street, Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Office
    • 45,804 SF
    Availability
    • 1 Space
    • 4,897 SF
    Year Built
    • 1972
    View Details
  • 300 E. Main St. - Durham
    300 E. Main St., Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Office
    • 30,517 SF
    Availability
    • 3 Spaces
    • 11,391 SF
    Year Built
    • 1925
    View Details
  • American Tobacco Campus - Durham
    406 & 410 Blackwell Street, Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Office
    • 46,998 SF
    Availability
    • 1 Space
    • 46,998 SF
    View Details
  • Diamond View II - Durham
    280 S Mangum Street, Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Office
    • 156,770 SF
    Availability
    • 2 Spaces
    • 41,157 SF
    Year Built
    • 2008
    View Details
  • Venable Center - Durham
    303 South Roxboro Street, Downtown Durham, Durham, NC
    For Lease
    • $36.50/SF/YR
    Property
    • Office
    • 85,886 SF
    Availability
    • 1 Space
    • 11,446 SF
    Year Built
    • 2006
    View Details
  • 201 West Main Street - Durham
    Coworking

    201 West Main Street

    American Underground
    201 West Main Street #100, Durham, NC
    Services
    • Open Workspace
    • Private Office
    Amenities
    View Details
  • 102 East Main Street - Durham
    Coworking

    102 East Main Street

    The Chill Place
    102 East Main Street #100, Durham, NC
    Services
    • Open Workspace
    • Meeting Room
    • Private Office
    Amenities
    View Details
  • The Roxboro at Venable Center - Durham
    464 East Pettigrew Street, Downtown Durham, Durham, NC
    For Lease
    • $39.50/SF/YR
    Property
    • Office
    • 210,410 SF
    Availability
    • 9 Spaces
    • 203,249 SF
    Year Built
    • 2022
    View Details
  • 100 E Parrish St - Durham
    100 E Parrish St, Downtown Durham, Durham, NC
    For Sale
    • $1,000,000
    Property
    • Office
    • 3,860 SF
    Year Built
    • 1984
    View Details
  • Rogers Alley - Durham
    107 East Parrish Street, Downtown Durham, Durham, NC
    For Lease
    • $29.50/SF/YR
    Property
    • Office
    • 6,485 SF
    Availability
    • 2 Spaces
    • 6,485 SF
    View Details
  • 555 Mangum - Durham
    555 South Mangum Street, Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Office
    • 242,063 SF
    Availability
    • 7 Spaces
    • 107,958 SF
    Year Built
    • 2020
    View Details
  • Ramseur Assemblage - Durham
    506/608 E Ramseur and 618 E Ramseur Street, Downtown Durham, Durham, NC
    For Sale
    • Subject to offer
    Property
    • Office
    • 27,200 SF
    View Details
  • Durham Kress - Durham
    101-103 W Main Street, Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Office
    • 24,500 SF
    Availability
    • 1 Space
    • 7,306 SF
    Year Built
    • 1907
    View Details
  • 204 South Gregson Street - Durham
    204 South Gregson Street, Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Office
    • 218,000 SF
    Availability
    • 1 Space
    • 218,000 SF
    Year Built
    • 2023
    View Details
  • 100 E Parrish St Suite 100 - Durham
    100 E Parrish St, Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Office
    • 2,000 SF
    Availability Contact for availability
    Year Built
    • 1984
    View Details
  • Brightleaf Square - Durham
    905 West Main Street, Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Retail
    • 139,785 SF
    Availability
    • 10 Spaces
    • 25,595 SF
    Year Built
    • 1904
    View Details
  • 112 S Duke St - Durham
    112 S Duke St, Downtown Durham, Durham, NC
    For Lease
    • Contact for pricing
    Property
    • Office
    • 16,203 SF
    Availability
    • 4 Spaces
    • 15,085 SF
    Year Built
    • 1910
    View Details

Commercial Spaces for Lease and Sale

If you are looking for commercial real estate for lease and sale in Downtown Durham, Durham, NC that is perfect for your business needs, look no further than the 27 listings that are currently available locally. Available spaces amount to a total of 787,018 square feet and span several popular locations and high-value submarkets. Commercial spaces currently listed in Downtown Durham, Durham, NC cover a wide range of needs in terms of size and range up to 218,000 square feet. Easily focus your search using the intuitive tools and filters available on this page and locate the perfect commercial real estate listing for you!

Market News

The 42Floors blog keeps you in the loop on commercial real estate news and market insights, as well as coworking and shared space trends.

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