The typical asking rate per listing is in the $10's per square foot per year. The Knoxville region is experiencing a decline in rates. In the last 3 months, the median rate fell $1 per sqft per year. That's a 6% decline in rent.
In the last 90 days, 157 listings have been made available, so you'll want to check back regularly for new listings. About 2% of the available leases in the Knoxville are subleases, so you will probably need to sign a longer term lease with the landlord directly. There aren't many listings below 2,000 square feet available, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 1,800 sqft. Most properties in this market are around 1 stories. Most buildings in this market were built in 1940 and are Class B.