Most listings are in the $40's per square foot per year. The Downtown Santa Fe region is experiencing a a boost in rates. In the last 3 months, the median rate increased $5 per sqft per year. That's a 11% increase in rent.
In the last 90 days, 3 listings have been listed, which means new listings most likley are leasing quickly. You'll want to be prepared to make an offer immediately. About 600% of the available space in the Downtown Santa Fe are subleases, so you might be able to sign a shorter term by taking over a previous lease. There aren't many listings below 2,000 square feet on the market, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 920 sqft. Most buildings in this market are around 2 stories. Most buildings in this area were built in 0 and are Class B.
This area is fairly equally mixed residential and commercial. Professional services is the dominant industry in this region. Most of the residents of Downtown Santa Fe work from home. Commuting between 20 and 25 minutes a day is the norm for those who opt to reside in this part of town.