Most listings are in the $20's per square foot per year. The South Loop region is going through a a boost in rates. In the last 3 months, the median rate went up $6 per sqft per year. That's a 29% increase in rent.
In the last 90 days, 13 listings have been made available, which means spaces most likley are going fast. You'll want to be prepared to make an offer immediately. About 62% of the office spaces in the South Loop are subleases, so you might be able to snag a great spot on a short term. There aren't many listings below 2,000 square feet posted, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 1,300 sqft. Most properties in this market are approximately 3 floors. Most buildings in this region were built in 1982 and are Class A.
This region is fairly equally mixed residential and commercial. Health care is the dominant industry in this market. Commute by bike is the most popular way to get to work amongst South Loop folk. Commuting between 30 and 45 minutes a day is the norm for those who opt to reside in this part of town.