On average, listings lease in the $20's per square foot per year. The Frederick submarket is going through a an increase in rates. In the last 3 months, the median rate increased $7 per sqft per year. That's a 38% increase in rent.
Compared to the rest of the Washington D.C. market, the Frederick region has less expensive rates, so you should have no trouble finding a great deal in this discounted region.
In the last 90 days, 65 listings have been posted online, so you'll want to check back regularly for new listings. There aren't many listings below 2,000 square feet posted, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 1,580 sqft. Most properties in this area are around 2 stories. Most buildings in this area were built in 1984 and are Class A.