Most listings are in the $40's per square foot per year. The Cambridge submarket is experiencing a an increase in rates. In the last 3 months, the median rate increased $9 per sqft per year. That's a 27% rise in rent.
Compared to the rest of the Greater Boston market, the Cambridge submarket has more expensive rates, and you'll have to negotiate above asking rent to be in this hot region.
In the last 90 days, 32 listings have been made available, which means listings might be going fast. You'll want to be prepared to tour spaces as quick as possible. About 3% of the available leases in the Cambridge are subleases, so you will probably need to sign a longer term lease with the landlord directly. There aren't many listings below 2,000 square feet posted, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 2,000 sqft. Most buildings in this market are around 5 stories. Most buildings in this region were built in 1970 and are Class A.