Most listings are in the $20's per square foot per year. The Fort Myers submarket is going through a a boost in rates. In the last 3 months, the median rate went up $1 per sqft per year. That's a 5% rise in rent.
In the last 90 days, 30 listings have been posted online, which means office spaces are probably going fast. You'll want to be prepared to make an offer immediately. There aren't many listings below 2,000 square feet on the market, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 1,600 sqft. Most properties in this market are around 2 stories. Most buildings in this area were built in 1985 and are Class B.