Most listings are in the $10's per square foot per year. The Fort Myers region is experiencing a decline in rates. In the last 3 months, the median rate fell $2 per sqft per year. That's a 12% decrease in rent.
In the last 90 days, 35 listings have been made available, which means leases are probably leasing quickly. You'll want to be prepared to make an offer immediately. There aren't many listings below 2,000 square feet posted, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 2,200 sqft. Most properties in this region are close to 2 floors. Most buildings in this area were built in 1985 and are Class B.