Most listings are in the $20's per square foot per year. The Littleton submarket is going through a an increase in rates. In the last 3 months, the median rate went up $3 per sqft per year. That's a 13% increase in rent.
Compared to the rest of the Denver Metro market, the Littleton submarket has smaller rates, so you should have no trouble finding a great deal in this discounted region.
In the last 90 days, 5 listings have been made available, which means leases most likley are leasing quickly. You'll want to be prepared to tour spaces as quick as possible. There aren't many listings below 2,000 square feet on the market, so finding a space for a small business might be tough.
Even though the median size is 2,610 sqft, there are still 0 leases below 2,000 sqft. Most properties in this area are around 2 floors. Most buildings in this area were built in 1983 and are Class B.