Compared to the rest of the Silicon Valley market, the Downtown San Mateo submarket has more expensive rates, and you'll have to negotiate above asking rent to be in this hot region.
In the last 90 days, 35 listings have been made available, which means leases might be going fast. You'll want to be prepared to make an offer immediately. About 9% of the available space in the Downtown San Mateo are subleases, so you will probably need to sign a longer term lease with the landlord directly. There aren't many listings below 2,000 square feet available, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 1,350 sqft. Most properties in this area are close to 3 floors. Most buildings in this market were built in 1968 and are Class B.
Not much of the real estate is used for commercial space, so it might be hard to find office space. Utilities is the dominant industry in this area. Commute by taxi is the most popular way to get to work amongst Downtown San Mateo folk. Commuting between 30 and 45 minutes a day is the norm for those who opt to reside in this part of town.