On average, listings lease in the $20's per square foot per year. The Palmdale submarket is going through a an increase in rates. In the last 3 months, the median rate went up $13 per sqft per year. That's a 85% rise in rent.
Compared to the rest of the Metropolitan Los Angeles market, the Palmdale submarket has smaller rates, so you should have no trouble finding a great deal in this undervalued region.
In the last 90 days, 4 listings have come on the market, which means leases most likley are leasing quickly. You'll want to be prepared to make an offer immediately. There aren't many listings below 2,000 square feet on the market, so finding a space for a small business might be tough.
Even though the median size is 4,270 sqft, there are still 0 listings below 2,000 sqft. Most buildings in this region are approximately 2 floors. Most buildings in this area were built in 2003 and are Class A.