Most listings are in the $20's per square foot per year. The Knoxville region is experiencing a decline in rates. In the last 3 months, the median rate fell $1 per sqft per year. That's a 3% decline in rent.
In the last 90 days, 38 listings have been posted online, which means spaces are probably leasing quickly. You'll want to be prepared to tour spaces as quick as possible. About 11% of the listings in the Knoxville are subleases, so you might be able to sign a shorter term by taking over a previous lease. There aren't many listings below 2,000 square feet on the market, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 2,060 sqft. Most properties in this area are close to 1 stories. Most buildings in this region were built in 1899 and are Class Class B.