The typical asking rate per listing is in the $10's per square foot per year. The Harrisburg region is going through a an increase in rates. In the last 3 months, the median rate rose $1 per sqft per year. That's a 5% rise in rent.
In the last 90 days, 30 listings have been listed, which means spaces might be leasing quickly. You'll want to be prepared to tour spaces as quick as possible. About 3% of the office spaces in the Harrisburg are subleases, so you will probably need to sign a longer term lease with the landlord directly. There aren't many listings below 2,000 square feet available, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 1,500 sqft. Most buildings in this region are approximately 3 floors. Most buildings in this market were built in 1935 and are Class B.