In the last 90 days, 1 listings have been posted online, which means listings most likley are leasing quickly. You'll want to be prepared to make an offer immediately. There aren't many listings below 2,000 square feet available, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 2,000 sqft. Most properties in this area are around 5 stories. Most buildings in this area were built in 1920.
Not much of the real estate is used for commercial space, so it might be hard to find office space. Waste services is the dominant industry in this region. Most of the folk of Lower East Side work from home. Commuting around 15 minutes a day is the norm for those who opt to reside in this part of town.