On average, listings lease in the $20's per square foot per year. The Henderson region is going through a a boost in rates. In the last 3 months, the median rate rose $1 per sqft per year. That's a 4% rise in rent.
Compared to the rest of the Las Vegas–Henderson–Paradise market, the Henderson submarket has lower rates, so you should have no trouble finding a great deal in this depreciated submarket.
In the last 90 days, 84 listings have been made available, so you'll want to check back regularly for new listings. About 4% of the listings in the Henderson are subleases, so you will probably need to sign a longer term lease with the landlord directly. There aren't many listings below 2,000 square feet available, so finding a space for a small business might be tough.
Even though the median size is 2,770 sqft, there are still 0 new availabilities below 2,000 sqft. Most buildings in this area are approximately 2 stories. Most buildings in this market were built in 2003 and are Class B.