On average, listings lease in the $10's per square foot per year. The Littleton region is experiencing a an increase in rates. In the last 3 months, the median rate went up $14 per sqft per year.
Compared to the rest of the Denver Metro market, the Littleton region has less expensive rates, so you should have no trouble finding a great deal in this undervalued region.
In the last 90 days, 8 listings have been made available, which means spaces most likley are going fast. You'll want to be prepared to tour spaces as quick as possible. About 250% of the available leases in the Littleton are subleases, so you might be able to find a shorter term or below market rent. There aren't many listings below 2,000 square feet available, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 2,330 sqft. Most properties in this area are close to 2 floors. Most buildings in this region were built in 1984 and are Class B.