The typical asking rate per listing is in the $20's per square foot per year. The Santa Cruz region is going through a decline in rates. In the last 3 months, the median rate fell $2 per sqft per year. That's a 8% decrease in rent.
In the last 90 days, 8 listings have been made available, which means office spaces most likley are going fast. You'll want to be prepared to make an offer immediately. About 13% of the listings in the Santa Cruz are subleases, so you might be able to find a shorter term or below market rent. There aren't many listings below 2,000 square feet on the market, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 2,130 sqft. Most buildings in this region are approximately 1 floors. Most buildings in this region were built in 1888 and are Class B.