On average, listings lease in the $20's per square foot per year. The Santa Cruz submarket is going through a a boost in rates. In the last 3 months, the median rate increased $1 per sqft per year. That's a 4% increase in rent.
In the last 90 days, 6 listings have come on the market, which means office spaces are probably leasing quickly. You'll want to be prepared to make an offer immediately. About 17% of the available leases in the Santa Cruz are subleases, so you might be able to snag a great spot on a short term. There aren't many listings below 2,000 square feet posted, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 1,400 sqft. Most buildings in this market are around 1 stories. Most buildings in this region were built in 1888 and are Class B.