Most listings are in the $20's per square foot per year. The Lower East submarket is going through a a rise in rates. In the last 3 months, the median rate increased $25 per sqft per year.
In the last 90 days, 12 listings have been posted online, which means listings are probably going fast. You'll want to be prepared to make an offer immediately. About 8% of the available space in the Lower East are subleases, so you will probably need to consider the implications of signing a direct lease with the building. There aren't many listings below 2,000 square feet posted, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 640 sqft. Most buildings in this market were built in 1989 and are Class A.
Not much of the real estate is used for commercial space, so it might be hard to find office space. Health care is the dominant industry in this area. Commute by walking is the most popular way to get to work amongst Lower East occupants. Commuting between 30 and 45 minutes a day is the norm for those who opt to reside in this part of town.