The typical asking rate per listing is in the $20's per square foot per year. The San Luis Obispo region is going through a decline in rates. In the last 3 months, the median rate fell $1 per sqft per year. That's a 3% decrease in rent.
In the last 90 days, 54 listings have been listed, so you'll want to check back regularly for new listings. About 6% of the available leases in the San Luis Obispo are subleases, so you will probably need to consider the implications of signing a direct lease with the building. There aren't many listings below 2,000 square feet available, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 1,330 sqft. Most buildings in this market are approximately 2 stories. Most buildings in this market were built in 2002 and are Class A.