The typical asking rate per listing is in the $20's per square foot per year. The San Luis Obispo region is going through a decline in rates. In the last 3 months, the median rate decreased $2 per sqft per year. That's a 5% decline in rent.
In the last 90 days, 27 listings have been posted online, which means new listings most likley are leasing quickly. You'll want to be prepared to tour spaces as quick as possible. About 15% of the available space in the San Luis Obispo are subleases, so you might be able to snag a great spot on a short term. There aren't many listings below 2,000 square feet posted, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 1,530 sqft. Most buildings in this region are approximately 2 floors. Most buildings in this region were built in 2009 and are Class A.