Most listings are in the $20's per square foot per year. The Southwest San Francisco submarket is going through a a boost in rates. In the last 3 months, the median rate increased $2 per sqft per year. That's a 8% rise in rent.
Compared to the rest of the Bay Area market, the Southwest San Francisco region has less expensive rates, so you should have no trouble finding a great deal in this depreciated submarket.
In the last 90 days, 20 listings have been posted online, which means new availabilities most likley are going fast. You'll want to be prepared to make an offer immediately. About 5% of the available leases in the Southwest San Francisco are subleases, so you will probably need to sign a longer term lease with the landlord directly. There aren't many listings below 2,000 square feet available, so finding a space for a small business might be tough.
Even though the median size is 2,660 sqft, there are still 0 leases below 2,000 sqft. Most buildings in this region are close to 2 stories. Most buildings in this region were built in 1933 and are Class B.
Not much of the real estate is used for commercial space, so it might be hard to find office space. Finance and insurance are the dominant industries in this region. Most of the occupants of Southwest San Francisco work from home. Commuting around 30 minutes a day is the norm for those who opt to reside in this part of town.