Compared to the rest of the Bay Area market, the Lower Nob Hill region has higher rates, and you'll need to make a great offer to be in this hot region.
In the last 90 days, 16 listings have come on the market, which means new availabilities are probably leasing quickly. You'll want to be prepared to tour spaces as quick as possible. About 50% of the listings in the Lower Nob Hill are subleases, so you might be able to sign a shorter term by taking over a previous lease. There aren't many listings below 2,000 square feet available, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 1,260 sqft. Most properties in this area are approximately 4 stories. Most buildings in this market were built in 1915 and are Class B.
Not much of the real estate is used for commercial space, so it might be hard to find office space. Health care is the dominant industry in this market. Most of the folk of Lower Nob Hill work from home. Commuting close to 15 minutes a day is the norm for those who opt to reside in this part of town.