The typical asking rate per listing is in the $20's per square foot per year. The Serra Mesa region is going through a a rise in rates. In the last 3 months, the median rate rose $1 per sqft per year. That's a 3% rise in rent.
Compared to the rest of the San Diego market, the Serra Mesa submarket has less expensive rates, so you should have no trouble finding a great deal in this depreciated region.
In the last 90 days, 2 listings have been listed, which means new listings most likley are leasing quickly. You'll want to be prepared to make an offer immediately. There aren't many listings below 2,000 square feet on the market, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 1,940 sqft. Most properties in this market are approximately 3 stories. Most buildings in this region were built in 1985 and are Class B.
Not much of the real estate is used for commercial space, so it might be hard to find office space. Arts, entertainment, and restaurants are the dominant industries in this region. Commute by motorcycle is the most popular way to get to work amongst Serra Mesa occupants. Commuting around 30 minutes a day is the norm for those who opt to reside in this part of town.