Most listings are in the $20's per square foot per year. The La Mesa region is going through a decrease in rates. In the last 3 months, the median rate decreased $2 per sqft per year. That's a 8% decrease in rent.
Compared to the rest of the San Diego market, the La Mesa region has lower rates, so you should have no trouble finding a great deal in this depreciated submarket.
In the last 90 days, 11 listings have been made available, which means new availabilities might be leasing quickly. You'll want to be prepared to tour spaces as quick as possible. About 64% of the listings in the La Mesa are subleases, so you might be able to sign a shorter term by taking over a previous lease. There aren't many listings below 2,000 square feet on the market, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 2,310 sqft. Most buildings in this market are approximately 2 stories. Most buildings in this area were built in 1979 and are Class C.