The typical asking rate per listing is in the $120's per square foot per year. The Upper East Side region is going through a a boost in rates. In the last 3 months, the median rate rose $11 per sqft per year. That's a 10% rise in rent.
Compared to the rest of the New York City market, the Upper East Side region has more expensive rates, and you'll need to pay a premium to be in this hot region.
In the last 90 days, 73 listings have been made available, so you'll want to check back regularly for new listings. About 4% of the available leases in the Upper East Side are subleases, so you will probably need to sign a longer term lease with the landlord directly. There aren't many listings below 2,000 square feet posted, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 1,890 sqft. Most properties in this area are approximately 5 stories. Most buildings in this region were built in 1920 and are Class A.
Not much of the real estate is used for commercial space, so it might be hard to find office space. Arts, entertainment, and restaurants are the dominant industries in this market. Most of the folk of Upper East Side work from home. Commuting between 30 and 45 minutes a day is the norm for those who opt to reside in this part of town.