In the last 90 days, 3 listings have been posted online, which means leases most likley are leasing quickly. You'll want to be prepared to make an offer immediately. There aren't many listings below 2,000 square feet on the market, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around sqft. Most properties in this market are approximately 5 floors. Most buildings in this region were built in 1920.
Not much of the real estate is used for commercial space, so it might be hard to find office space. Waste services is the dominant industry in this area. Most of the folk of Lower East Side work from home. Commuting close to 15 minutes a day is the norm for those who opt to reside in this part of town.