Most listings are in the $40's per square foot per year. The Downtown Santa Fe region is experiencing a a boost in rates. In the last 3 months, the median rate increased $5 per sqft per year. That's a 11% rise in rent.
In the last 90 days, 3 listings have been posted online, which means leases are probably going fast. You'll want to be prepared to make an offer immediately. About 600% of the listings in the Downtown Santa Fe are subleases, so you might be able to find a shorter term or below market rent. There aren't many listings below 2,000 square feet available, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 920 sqft. Most buildings in this region are around 2 floors. Most buildings in this region were built in 0 and are Class B.
This market is fairly equally mixed residential and commercial. Professional services is the dominant industry in this region. Most of the occupants of Downtown Santa Fe work from home. Commuting between 20 and 25 minutes a day is the norm for those who opt to reside in this part of town.