Most listings are in the $0's per square foot per year. The Lowell region is experiencing a decline in rates. In the last 3 months, the median rate fell $18 per sqft per year. That's a 100% decline in rent.
In the last 90 days, 5 listings have been listed, which means office spaces most likley are going fast. You'll want to be prepared to tour spaces as quick as possible. About 20% of the office spaces in the Lowell are subleases, so you might be able to sign a shorter term by taking over a previous lease. There aren't many listings below 2,000 square feet posted, so finding a space for a small business might be tough.
Even though the median size is 5,650 sqft, there are still 0 listings below 2,000 sqft. Most properties in this region are around 4 stories. Most buildings in this area were built in 1977 and are Class B.