On average, listings lease in the $40's per square foot per year. The DePaul region is going through a decrease in rates. In the last 3 months, the median rate fell $2 per sqft per year. That's a 5% decrease in rent.
Compared to the rest of the Chicagoland market, the DePaul submarket has greater rates, and you'll have to negotiate above asking rent to be in this hot region.
In the last 90 days, 4 listings have been made available, which means office spaces are probably leasing quickly. You'll want to be prepared to tour spaces as quick as possible. There aren't many listings below 2,000 square feet available, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 1,800 sqft. Most properties in this market are close to 3 stories. Most buildings in this area were built in 1925 and are Class C.