The typical asking rate per listing is in the $10's per square foot per year. The Frederick submarket is going through a decline in rates. In the last 3 months, the median rate decreased $9 per sqft per year. That's a 37% decline in rent.
In the last 90 days, 2 listings have been posted online, which means new listings most likley are going fast. You'll want to be prepared to make an offer immediately. There aren't many listings below 2,000 square feet available, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 2,400 sqft. Most buildings in this area are around 2 floors. Most buildings in this area were built in 1990 and are Class A.