The typical asking rate per listing is in the $20's per square foot per year. The San Luis Obispo region is going through a decline in rates. In the last 3 months, the median rate fell $4 per sqft per year. That's a 14% decline in rent.
In the last 90 days, 20 listings have been listed, which means spaces are probably going fast. You'll want to be prepared to make an offer immediately. About 60% of the available leases in the San Luis Obispo are subleases, so you might be able to snag a great spot on a short term. There aren't many listings below 2,000 square feet on the market, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 1,220 sqft. Most buildings in this market are approximately 2 floors. Most buildings in this region were built in 2009 and are Class A.