Compared to the rest of the Bay Area market, the Potrero Hill region has more expensive rates, and you'll need to make a great offer to be in this hot region.
In the last 90 days, 15 listings have been listed, which means new listings most likley are leasing quickly. You'll want to be prepared to make an offer immediately. About 7% of the listings in the Potrero Hill are subleases, so you will probably need to consider the implications of signing a direct lease with the building. There aren't many listings below 2,000 square feet posted, so finding a space for a small business might be tough.
Even though the median size is 4,910 sqft, there are still 0 new listings below 2,000 sqft. Most properties in this market are around 2 stories. Most buildings in this market were built in 1961 and are Class B.
Not much of the real estate is used for commercial space, so it might be hard to find office space. Health care is the dominant industry in this region. Most of the occupants of Potrero Hill work from home. Commuting around an hour a day is the norm for those who opt to reside in this part of town.