On average, listings lease in the $70's per square foot per year. The Lower Nob Hill submarket is going through a a rise in rates. In the last 3 months, the median rate increased $3 per sqft per year. That's a 4% rise in rent.
Compared to the rest of the Bay Area market, the Lower Nob Hill submarket has greater rates, and you'll have to negotiate above asking rent to be in this hot submarket.
In the last 90 days, 18 listings have been listed, which means listings most likley are going fast. You'll want to be prepared to make an offer immediately. About 6% of the listings in the Lower Nob Hill are subleases, so you will probably need to consider the implications of signing a direct lease with the building. There aren't many listings below 2,000 square feet on the market, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 1,400 sqft. Most properties in this area are close to 4 stories. Most buildings in this market were built in 1915 and are Class B.
Not much of the real estate is used for commercial space, so it might be hard to find office space. Health care is the dominant industry in this area. Most of the occupants of Lower Nob Hill work from home. Commuting around 15 minutes a day is the norm for those who opt to reside in this part of town.