Compared to the rest of the San Diego market, the Otay Mesa region has lower rates, so you should have no trouble finding a great deal in this undervalued region.
In the last 90 days, 16 listings have been posted online, which means spaces most likley are leasing quickly. You'll want to be prepared to make an offer immediately. About 100% of the available space in the Otay Mesa are subleases, so you might be able to snag a great spot on a short term. There aren't many listings below 2,000 square feet posted, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 1,000 sqft. Most buildings in this region are approximately 2 stories. Most buildings in this area were built in 1989 and are Class A.
This region is fairly equally mixed residential and commercial. Health care is the dominant industry in this area. Commute by car is the most popular way to get to work amongst Otay Mesa occupants. Commuting approximately 20 minutes a day is the norm for those who opt to reside in this part of town.