In the last 90 days, 29 listings have been made available, which means leases most likley are leasing quickly. You'll want to be prepared to make an offer immediately. There aren't many listings below 2,000 square feet available, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 2,390 sqft. Most properties in this area are approximately 3 floors. Most buildings in this area were built in 1931 and are Class B.
Health care is the dominant industry in this region. Most of the folk of Downtown Roanoke work from home. Commuting close to 20 minutes a day is the norm for those who opt to reside in this part of town.