Compared to the rest of the New York City market, the East Harlem submarket has lower rates, so you should have no trouble finding a great deal in this depreciated region.
In the last 90 days, 12 listings have been posted online, which means new availabilities most likley are going fast. You'll want to be prepared to make an offer immediately. There aren't many listings below 2,000 square feet posted, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 950 sqft. Most properties in this area are approximately 5 stories. Most buildings in this market were built in 1920 and are Class A.
Not much of the real estate is used for commercial space, so it might be hard to find office space. Health care is the dominant industry in this area. Commute by bike is the most popular way to get to work amongst East Harlem residents. Commuting close to an hour a day is the norm for those who opt to reside in this part of town.