In the last 90 days, 10 listings have been listed, which means new availabilities most likley are leasing quickly. You'll want to be prepared to make an offer immediately. There aren't many listings below 2,000 square feet available, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 870 sqft. Most buildings in this market are approximately 2 stories. Most buildings in this area were built in 0 and are Class B.
A large portion of this area is residential, but there's plenty of office_space. Professional services is the dominant industry in this area. Most of the folk of Downtown Santa Fe work from home. Commuting between 20 and 25 minutes a day is the norm for those who opt to reside in this part of town.