On average, listings lease in the $30's per square foot per year. The Downtown Santa Fe submarket is going through a a boost in rates. In the last 3 months, the median rate rose $9 per sqft per year. That's a 33% rise in rent.
In the last 90 days, 3 listings have been made available, which means new availabilities most likley are leasing quickly. You'll want to be prepared to make an offer immediately. There aren't many listings below 2,000 square feet on the market, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 500 sqft. Most buildings in this area are close to 2 stories. Most buildings in this region were built in 0 and are Class B.
This area is fairly equally mixed residential and commercial. Professional services is the dominant industry in this market. Most of the folk of Downtown Santa Fe work from home. Commuting between 20 and 25 minutes a day is the norm for those who opt to reside in this part of town.