On average, listings lease in the $10's per square foot per year. The Fort Myers region is experiencing a decrease in rates. In the last 3 months, the median rate decreased $2 per sqft per year. That's a 9% decrease in rent.
In the last 90 days, 34 listings have come on the market, which means spaces are probably leasing quickly. You'll want to be prepared to tour spaces as quick as possible. About 3% of the available leases in the Fort Myers are subleases, so you will probably need to sign a longer term lease with the landlord directly. There aren't many listings below 2,000 square feet posted, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 1,900 sqft. Most properties in this market are close to 2 floors. Most buildings in this region were built in 1985 and are Class B.