Most listings are in the $30's per square foot per year. The Simi Valley region is going through a a boost in rates. In the last 3 months, the median rate increased $2 per sqft per year. That's a 8% rise in rent.
Compared to the rest of the Metropolitan Los Angeles market, the Simi Valley region has less expensive rates, so you should have no trouble finding a great deal in this depreciated region.
In the last 90 days, 8 listings have been listed, which means listings most likley are leasing quickly. You'll want to be prepared to make an offer immediately. There aren't many listings below 2,000 square feet available, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 1,940 sqft. Most properties in this region are approximately 2 floors. Most buildings in this region were built in 1986 and are Class B.