The typical asking rate per listing is in the $20's per square foot per year. The Santa Cruz region is going through a decrease in rates. In the last 3 months, the median rate decreased $13 per sqft per year. That's a 40% decline in rent.
In the last 90 days, 50 listings have been listed, so you'll want to check back regularly for new listings. About 4% of the available space in the Santa Cruz are subleases, so you will probably need to consider the implications of signing a direct lease with the building. There aren't many listings below 2,000 square feet available, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 1,400 sqft. Most buildings in this region are around 2 stories. Most buildings in this market were built in 1967 and are Class B.