Most listings are in the $20's per square foot per year. The Santa Cruz region is going through a a rise in rates. In the last 3 months, the median rate rose $2 per sqft per year. That's a 7% increase in rent.
In the last 90 days, 29 listings have been made available, which means listings are probably leasing quickly. You'll want to be prepared to tour spaces as quick as possible. There aren't many listings below 2,000 square feet posted, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 2,100 sqft. Most properties in this region are close to 2 floors. Most buildings in this area were built in 1972 and are Class B.