Compared to the rest of the Bay Area market, the Potrero Hill region has greater rates, and you'll need to make a great offer to be in this hot region.
In the last 90 days, 10 listings have been listed, which means new availabilities most likley are going fast. You'll want to be prepared to make an offer immediately. About 10% of the listings in the Potrero Hill are subleases, so you will probably need to consider the implications of signing a direct lease with the building. There aren't many listings below 2,000 square feet available, so finding a space for a small business might be tough.
Even though the median size is 5,590 sqft, there are still 0 new availabilities below 2,000 sqft. Most properties in this area are approximately 2 floors. Most buildings in this area were built in 1961 and are Class B.
Not much of the real estate is used for commercial space, so it might be hard to find office space. Health care is the dominant industry in this area. Most of the occupants of Potrero Hill work from home. Commuting close to an hour a day is the norm for those who opt to reside in this part of town.