Compared to the rest of the Bay Area market, the Potrero Hill submarket has more expensive rates, and you'll have to negotiate above asking rent to be in this hot region.
In the last 90 days, 15 listings have been made available, which means new availabilities are probably leasing quickly. You'll want to be prepared to make an offer immediately. About 7% of the office spaces in the Potrero Hill are subleases, so you will probably need to consider the implications of signing a direct lease with the building. There aren't many listings below 2,000 square feet available, so finding a space for a small business might be tough.
Even though the median size is 4,910 sqft, there are still 0 new listings below 2,000 sqft. Most buildings in this market are close to 2 floors. Most buildings in this market were built in 1961 and are Class B.
Not much of the real estate is used for commercial space, so it might be hard to find office space. Health care is the dominant industry in this market. Most of the folk of Potrero Hill work from home. Commuting around an hour a day is the norm for those who opt to reside in this part of town.