On average, listings lease in the $60's per square foot per year. The Mission District submarket is going through a a boost in rates. In the last 3 months, the median rate rose $5 per sqft per year. That's a 8% increase in rent.
Compared to the rest of the Bay Area market, the Mission District region has higher rates, and you'll need to make a great offer to be in this hot region.
In the last 90 days, 27 listings have been posted online, which means leases are probably leasing quickly. You'll want to be prepared to make an offer immediately. About 4% of the available space in the Mission District are subleases, so you will probably have to focus your search on direct office leases. There aren't many listings below 2,000 square feet on the market, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 1,500 sqft. Most properties in this area are close to 2 stories. Most buildings in this market were built in 1914 and are Class B.
Not much of the real estate is used for commercial space, so it might be hard to find office space. Utilities is the dominant industry in this market. Commute by public transit is the most popular way to get to work amongst Mission District occupants. Commuting around 10 minutes a day is the norm for those who opt to reside in this part of town.