On average, listings lease in the $20's per square foot per year. The Otay Mesa region is going through a a rise in rates. In the last 3 months, the median rate rose $29 per sqft per year.
Compared to the rest of the San Diego market, the Otay Mesa region has less expensive rates, so you should have no trouble finding a great deal in this discounted submarket.
In the last 90 days, 16 listings have been made available, which means new listings most likley are leasing quickly. You'll want to be prepared to make an offer immediately. About 69% of the office spaces in the Otay Mesa are subleases, so you might be able to snag a great spot on a short term. There aren't many listings below 2,000 square feet on the market, so finding a space for a small business might be tough.
The standard measurement for office space in this area is around 980 sqft. Most buildings in this area are close to 2 floors. Most buildings in this area were built in 1989 and are Class A.
This area is fairly equally mixed residential and commercial. Health care is the dominant industry in this region. Commute by car is the most popular way to get to work amongst Otay Mesa folk. Commuting close to 20 minutes a day is the norm for those who opt to reside in this part of town.