The typical asking rate per listing is in the $10's per square foot per year. The Center City region is going through a a rise in rates. In the last 3 months, the median rate went up $20 per sqft per year.
In the last 90 days, 94 listings have come on the market, so you'll want to check back regularly for new listings. About 30% of the available leases in the Center City are subleases, so you might be able to find a shorter term or below market rent. There aren't many listings below 2,000 square feet posted, so finding a space for a small business might be tough.
Even though the median size is 7,240 sqft, there are still 0 new availabilities below 2,000 sqft. Most buildings in this region are around 2 stories. Most buildings in this area were built in 1947 and are Class C.
Professional services is the dominant industry in this region. Most of the folk of Center City work from home. Commuting under 5 minutes a day is the norm for those who opt to reside in this part of town.